Anti-Zebrafish DeltaC [zdc2]

Delta proteins activate Notch through a binding reaction that depends on their extracellular domains. During somitogenesis, Notch signalling via DeltaC keeps the oscillations of neighbouring cells in synchrony. DeltaC is also expressed in subsets of cells in the nervous system and elsewhere.

Contributors

Inventor Institute
Gavin Wright Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151510
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell biology;Developmental biology;Neurobiology
Application: ELISA ; FACS ; IHC ; IF ; WB
Target: Zebrafish DeltaC
Reactivity: Zebrafish
Clone: zdc2
Host: Mouse
Class: Monoclonal
Product description: Delta proteins activate Notch through a binding reaction that depends on their extracellular domains. During somitogenesis, Notch signalling via DeltaC keeps the oscillations of neighbouring cells in synchrony. DeltaC is also expressed in subsets of cells in the nervous system and elsewhere.
Conjugation: Unconjugated
Isotype: IgG2a
Immunogen: Extracellular region of zebrafish DeltaC protein
Myeloma used: Sp2/0-Ag14
Target background: Delta proteins activate Notch through a binding reaction that depends on their extracellular domains. During somitogenesis, Notch signalling via DeltaC keeps the oscillations of neighbouring cells in synchrony. DeltaC is also expressed in subsets of cells in the nervous system and elsewhere.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -80° C
Shipping conditions: Dry ice
References:

Gallagher et al. 2017. Dev Biol. 429(1):225-239. PMID: 28648842.

Quillien et al. 2014. Development. 141(7):1544-52. PMID: 24598161.

Wright et al. 2011. Development. 138(14):2947-56. PMID: 21653612.

DeltaC and DeltaD interact as Notch ligands in the zebrafish segmentation clock.

Giudicelli et al. 2007. PLoS Biol. 5(6):e150. PMID: 17535112.

Setting the tempo in development: an investigation of the zebrafish somite clock mechanism.

Images

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Adapted from Giudicelli et al. 2007. PLoS Biol. 5(6)

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