Cat. #151058
Anti-XPA [5A2]
Cat. #: 151058
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: XPA
Class: Monoclonal
Application: ELISA ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Rick Wood
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-XPA [5A2]
- Research fields: Genetics
- Clone: 5A2
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 40 kDa
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; WB
- Description: XPA binds to the Replication Protein A (RPA) and is a core component of the nucleotide excision repair pathway. XPA is involved in one of the complementation groups of the heritable condition Xeroderma pigmentosum, where defects in nucleotide excision repair result in increased susceptibility to mutagens including UV.
- Immunogen: HIS-tagged recombinant human XPA protein.
- Isotype: IgG1
- Myeloma used: Sp2/0-Ag14
- Recommended controls: LS174T, MCF-7 cells or human tonsil
Target Details
- Target: XPA
- Molecular weight: 40 kDa
- Tissue cell line specificity: LS174T, MCF-7 cells or human tonsil
- Target background: XPA binds to the Replication Protein A (RPA) and is a core component of the nucleotide excision repair pathway. XPA is involved in one of the complementation groups of the heritable condition Xeroderma pigmentosum, where defects in nucleotide excision repair result in increased susceptibility to mutagens including UV.
Applications
- Application: ELISA ; WB
Handling
- Format: Liquid
- Concentration: 0.9-1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Wei et al. 2005. Cancer Epidemiol Biomarkers Prev. 14(8):1961-6. PMID: 16103444.
- Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck.
- Welsh et al. 2004. Int J Cancer. 110(3):352-61. PMID: 15095299.
- Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines.
- Kberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455.
- Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.
