XPA binds to the Replication Protein A (RPA) and is a core component of the nucleotide excision repair pathway. XPA is involved in one of the complementation groups of the heritable condition Xeroderma pigmentosum, where defects in nucleotide excision repair result in increased susceptibility to mutagens including UV.
| Inventor | Institute |
|---|---|
| Rick Wood | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| SKU: | 151058 |
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| Product description: | XPA binds to the Replication Protein A (RPA) and is a core component of the nucleotide excision repair pathway. XPA is involved in one of the complementation groups of the heritable condition Xeroderma pigmentosum, where defects in nucleotide excision repair result in increased susceptibility to mutagens including UV. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 40 kDa |
| Immunogen: | HIS-tagged recombinant human XPA protein. |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 151058 |
|---|---|
| Provenance and Ownership: | The Anti-XPA [5A2] is owned by Cancer Research UK. CancerTools supplies the Anti-XPA [5A2] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-XPA [5A2] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Genetics |
| Application: | ELISA ; WB |
| Target: | XPA |
| Reactivity: | Human |
| Clone: | 5A2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | XPA binds to the Replication Protein A (RPA) and is a core component of the nucleotide excision repair pathway. XPA is involved in one of the complementation groups of the heritable condition Xeroderma pigmentosum, where defects in nucleotide excision repair result in increased susceptibility to mutagens including UV. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Wei et al. 2005. Cancer Epidemiol Biomarkers Prev. 14(8):1961-6. PMID: 16103444. Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck. Welsh et al. 2004. Int J Cancer. 110(3):352-61. PMID: 15095299. Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines. Kberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455. Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours. |
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