Cat. #151528
Anti-von Willebrand Factor [RFF-VIII:R/1]
Cat. #: 151528
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Von Willebrand factor (VWF)
Class: Monoclonal
Application: ELISA ; FACS ; IF ; Fn ; RIA ; WB
Reactivity: Primate
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Alison Goodall
Institute: University College London (UCL)
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-von Willebrand Factor [RFF-VIII:R/1]
- Research fields: Stem cell biology;Tissue-specific biology
- Clone: RFF-VIII:R/1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Reactivity: Primate
- Host: Mouse
- Application: ELISA ; FACS ; IF ; Fn ; RIA ; WB
- Description: Anti-Anti-Von Willebrand Factor [RFF-VIII:R/1] specifically binds to human factor VIII related antigen (VIII:RAg) in plasma and in vascular endothelial cells but has no reactivity with factor VIII procoagulant antigen (VIII:cAg). This antibody is a potent inhibitor of von Willebrand factor activity in that it can totally neutralise risocetin-induced aggregation of platelet rich plasma and inhibit platelet adhesion at high flow rates. RFF-VIII:R/2 can be used in a one-stage, fluid phase immuno...
- Immunogen: Purified human Factor VIII-VWF complex
- Isotype: IgG1 kappa
- Myeloma used: P3/NS1/1-Ag4.1
Target Details
- Target: Von Willebrand factor (VWF)
- Tissue cell line specificity: Mouse
- Target background: Anti-Anti-Von Willebrand Factor [RFF-VIII:R/1] specifically binds to human factor VIII related antigen (VIII:RAg) in plasma and in vascular endothelial cells but has no reactivity with factor VIII procoagulant antigen (VIII:cAg). This antibody is a potent inhibitor of von Willebrand factor activity in that it can totally neutralise risocetin-induced aggregation of platelet rich plasma and inhibit platelet adhesion at high flow rates. RFF-VIII:R/2 can be used in a one-stage, fluid phase immuno...
Applications
- Application: ELISA ; FACS ; IF ; Fn ; RIA ; WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Shipping conditions: Dry ice
References
- [Use of RFF-VIII:R/1 in the purification of FVIII]
- Murdock et al. 1997. Thromb Haemost. 78(4):1272-7. PMID: 9364997.
- von Willebrand factor activity detected in a monoclonal antibody-based ELISA: an alternative to the ristocetin cofactor platelet agglutination assay for diagnostic use.
- Takase et al. 1987. Br J Haematol. 66(4):497-502. PMID: 3117089.
- Production of factor VIII deficient plasma by immunodepletion using three monoclonal antibodies.
- McCraw et al. 1987. Thromb Res. 45(1):1...
