Anti-TNC-C [4C2.1]

Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are nearly absent in extracellular matrix of normal adult tissues but upregulated in malignant tissues. Both FN-EDB and TNC-C are developed as targets of antibody-based therapies.This series of antibodies has been validated in vitro against glioblastoma (GBM) and prostate carcinoma xenografts, and to non-malignant angiogenic neovessels induced […]

Contributors

Inventor Institute
Tambet Teesalu University of Tartu
Cat. #: 160463
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Cell biology
Application: ELISA ; IHC ; IF
Target: Tenascin-C, TNC-C
Reactivity: Human
Host: Mouse
Class: Monoclonal
Product description: Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are nearly absent in extracellular matrix of normal adult tissues but upregulated in malignant tissues. Both FN-EDB and TNC-C are developed as targets of antibody-based therapies.This series of antibodies has been validated in vitro against glioblastoma (GBM) and prostate carcinoma xenografts, and to non-malignant angiogenic neovessels induced by VEGF-overexpression. Please see our related anti-FN-EDB antibodies from University of Tartu.
Conjugation: Unconjugated
Target background: Oncofetal fibronectin (FN-EDB) and tenascin-C C domain (TNC-C) are nearly absent in extracellular matrix of normal adult tissues but upregulated in malignant tissues. Both FN-EDB and TNC-C are developed as targets of antibody-based therapies. This series of antibodies has been validated in vitro against glioblastoma (GBM) and prostate carcinoma xenografts, and to non-malignant angiogenic neovessels induced by VEGF-overexpression. Please see our related anti-FN-EDB antibodies from Universit…
Format: Liquid
Shipping conditions: Dry ice
References:

Lingasamy et al. 2019. Biomaterials. 219:119373. PMID: 31374479.

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