A mouse monoclonal antibody recognising the gamma delta T cell receptor, used to detect and study gamma delta T cells in immune cell research.
| Institute |
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| Netherlands Cancer Institute |
| SKU: | 154750 |
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| Product description: | Anti-TCR gamma delta [11F2] monoclonal antibody is a mouse monoclonal antibody that recognises the human gamma delta T cell receptor. It is used to detect and study gamma delta T cells, supporting research into T cell receptor expression, gamma delta T cell biology and immune cell phenotyping. Clone 11F2 has been reported to recognise a framework epitope of the human gamma delta T cell receptor. This antibody reacts with human gamma delta T cell receptor in both native and denatured states. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Purified native TCRg/d |
| Myeloma used: | Sp2/0-Ag14 |
| Cat. #: | 154750 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction;Immunology |
| Application: | ELISA ; FACS ; IHC ; IP |
| Target: | TCR yd |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | The T-cell receptor (TCR) is a molecule found on the surface of T cells, or T lymphocytes, that is responsible for recognising fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. The TCR is composed of two different protein chains. In humans, in 95% of T cells the TCR consists of an alpha chain and a beta chain, whereas in 5% of T cells the TCR consists of gamma and delta (y/d) chains. This ratio changes during ontogeny and in diseased states such as leukaemia, as well as autoimmune diseases like psoriasis. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Vroom et al. 1991. J Clin Pathol. 44(12):1012-7. PMID: 1838746. Bos et al. 1990. J Invest Dermatol. 94(1):37-42. PMID: 1688597. Borst et al. 1988. J Exp Med. 167(5):1625-44. PMID: 2966845. |
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