TCP1, (a constituent of chaperone-containing TCP-1, CCT) is a ~60 kDa protein constitutively expressed in almost all eukaryotic cells and upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin.
| Inventor | Institute |
|---|---|
| Keith Willison | The Institute of Cancer Research |
| SKU: | 151321 |
|---|---|
| Product description: | TCP1, (a constituent of chaperone-containing TCP-1, CCT) is a ~60 kDa protein constitutively expressed in almost all eukaryotic cells and upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2c |
| Immunogen: | C-terminal half of the full length murine TCP protein |
| Myeloma used: | Y3.AG.1.2.3 |
| Cat. #: | 151321 |
|---|---|
| Provenance and Ownership: | The Anti-TCP1 [23c (CTA-123)] is owned by Cancer Research UK. CancerTools supplies the Anti-TCP1 [23c (CTA-123)] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-TCP1 [23c (CTA-123)] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Apoptosis and autophagy; Cancer; Cell biology |
| Application: | IHC ; IF ; IP ; WB |
| Target: | TCP1 (T-complex polypeptide 1) |
| Reactivity: | Chicken ; Dog ; Hamster ; Mouse ; Rat |
| Clone: | 23c (CTA-123) |
| Host: | Rat |
| Class: | Monoclonal |
| Target background: | TCP1, (a constituent of chaperone-containing TCP-1, CCT) is a ~60 kDa protein constitutively expressed in almost all eukaryotic cells and upregulated during spermatogenesis. It is found in the cytosol as a subunit of a hetero-oligomeric chaperone that is known to be involved in the folding of actin and tubulin. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Lobanova K et al, 2013. PNAS 110(24):9986-91 PMID 23716657 Sternlicht et al. 1993. Proc Natl Acad Sci U S A. 90(20):9422-6. PMID: 8105476. The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo. Harrison-Lavoie et al. 1993. EMBO J. 12(7):2847-53. PMID: 8335000. A 102 kDa subunit of a Golgi-associated particle has homology to beta subunits of trimeric G proteins. Willison et al. 1989. Cell. 57(4):621-32. PMID: 2655925. The t complex polypeptide 1 (TCP-1) is associated with the cytoplasmic aspect of Golgi membranes. |
|---|
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.