S100A9 is a cytosolic calcium-binding protein that forms a heterodimer. S100A9 is expressed in peripheral blood monocytes, neutrophils and keratinocytes (mature). Expression is lost on tissue maturation of monocytes to macrophages. S100A9 may be associated with monocyte and neutrophil activation and the accumulation of these cells in inflammatory sites.
| Inventor | Institute |
|---|---|
| Nancy Hogg | Cancer Research UK, London Research Institute: Lincoln's Inn Fields |
| Cat. #: | 151216 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction;Immunology |
| Application: | ELISA ; FACS ; IHC ; IF ; IP ; RIA ; WB |
| Target: | S100A9 (MRP14) |
| Reactivity: | Human |
| Clone: | 1H9 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | S100A9 is a cytosolic calcium-binding protein that forms a heterodimer. S100A9 is expressed in peripheral blood monocytes, neutrophils and keratinocytes (mature). Expression is lost on tissue maturation of monocytes to macrophages. S100A9 may be associated with monocyte and neutrophil activation and the accumulation of these cells in inflammatory sites. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human S100A9 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | S100A9 is a cytosolic calcium-binding protein that forms a heterodimer. S100A9 is expressed in peripheral blood monocytes, neutrophils and keratinocytes (mature). Expression is lost on tissue maturation of monocytes to macrophages. S100A9 may be associated with monocyte and neutrophil activation and the accumulation of these cells in inflammatory sites. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Zhu et al. 2013. Int J Cancer. 132(5):1051-9. PMID: 22864818. Roles of galectin-7 and S100A9 in cervical squamous carcinoma: Clinicopathological and in vitro evidence. Robinson et al. 2002. J Biol Chem. 277(5):3658-65. PMID: 11723110. The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells. |
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