During genetic recombination and post replication repair of DNA damage, RuvA and RuvB (a helicase) act in a complex to promote branch migration of Holliday junctions and RuvC (an endonuclease) cleaves Holliday junctions.
| Inventor | Institute |
|---|---|
| Stephen West | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151055 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Microbiology;Genetics |
| Application: | ELISA ; IHC ; IP ; RIA ; WB |
| Target: | Ruv B protein |
| Reactivity: | E.coli |
| Clone: | RuvB 4G5/1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | During genetic recombination and post replication repair of DNA damage, RuvA and RuvB (a helicase) act in a complex to promote branch migration of Holliday junctions and RuvC (an endonuclease) cleaves Holliday junctions. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 37 kDa |
| Immunogen: | Ruv B protein from E. Coli |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | During genetic recombination and post replication repair of DNA damage, RuvA and RuvB (a helicase) act in a complex to promote branch migration of Holliday junctions and RuvC (an endonuclease) cleaves Holliday junctions. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Davies et al. 1998. Curr Biol. 8(12):725-7. PMID: 9637927. Formation of RuvABC-Holliday junction complexes in vitro. Eggleston et al. 1997. Cell. 89(4):607-17. PMID: 9160752. In vitro reconstitution of the late steps of genetic recombination in E. coli. |
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