Cat. #151192
Anti-Rab11a [STo 7C10]
Cat. #: 151192
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: Rab11a
Class: Monoclonal
Application: ELISA ; IP ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Sharon Tooze
Institute: Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Rab11a [STo 7C10]
- Research fields: Cancer;Cell signaling and signal transduction
- Clone: STo 7C10
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IP ; WB
- Description: Rab11a is a member of the Rab family of Ras-like small GTPases, which regulate membrane trafficking events (e.g. vesicle recycling). Regulates endocytic recycling, may exert its functions by interacting with multiple effector proteins in different complexes & acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes.
- Immunogen: Rab11a peptide KQMSDRRENDM
- Isotype: IgG1
Target Details
- Target: Rab11a
- Target background: Rab11a is a member of the Rab family of Ras-like small GTPases, which regulate membrane trafficking events (e.g. vesicle recycling). Regulates endocytic recycling, may exert its functions by interacting with multiple effector proteins in different complexes & acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes.
Applications
- Application: ELISA ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1.1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
