JC1 detects a nuclear antigen, distinct from Ki67, present in proliferating cells. It is useful as a marker of proliferation in cases such as squamous cell carcinoma where the Ki67 index cannot be determined.
| Inventor | Institute |
|---|---|
| Jacqueline Cordell | University of Oxford |
| Cat. #: | 151401 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Neurobiology |
| Application: | IHC ; IF ; WB |
| Target: | Proliferation marker |
| Reactivity: | Human |
| Clone: | JC1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | JC1 detects a nuclear antigen, distinct from Ki67, present in proliferating cells. It is useful as a marker of proliferation in cases such as squamous cell carcinoma where the Ki67 index cannot be determined. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 212 kDa and 123 kDa |
| Immunogen: | Pokeweed-stimulated lymphocytes |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Li et al. 2017. J Exp Clin Cancer Res. 36(1):58. PMID: 28427443. Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2. Wang et al. 2016. Am J Cancer Res. 6(6):1331-44. PMID: 27429847. EMMPRIN, SP1 and microRNA-27a mediate physcion 8-O-?-glucopyranoside-induced apoptosis in osteosarcoma cells. Zhang et al. 2016. J Med Chem. 59(7):3562-8. PMID: 27006991. Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation. Garrido et al. 1992. J Clin Pathol. 45(10):860-5. PMID: 1430255. Monoclonal antibody JC1: new reagent for studying cell proliferation. |
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