Monoclonal antibody which detects PLA2R, the major antigen for idiopathic membranous nephropathy.
| Inventor | Institute |
|---|---|
| Paul Brenchley | University of Manchester |
| Cat. #: | 152570 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction;Metabolism;Tissue-specific biology |
| Application: | FACS ; IHC ; IF ; WB |
| Target: | Phospholipase A2 receptor 1 |
| Reactivity: | Human |
| Clone: | 1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Monoclonal antibody which detects PLA2R, the major antigen for idiopathic membranous nephropathy. Background and Research Application PLA2R is the major auto-antigen in the autoimmune kidney disease, membranous nephropathy. Detection of PLA2R antigen by IHC in the immune complexes present in the glomerular basement membrane is used as a diagnostic marker for the disease. PLA2R is also involved in clearance followed by suppression of their potent enzymatic activities of secretory phospholipas… |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Immunogen: | Human PLA2R extracellular sequence N-C3 (containing domains N-terminal Cysteine rich-FibII-CTLD1-CTLD2-CTLD3). Genbank acc no. U17033; amino acids 20-663 Recombinant protein expressed in HEK 293-EBNA-1 cells |
| Immunogen Uniprot ID: | Q13018 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Monoclonal antibody which detects PLA2R, the major antigen for idiopathic membranous nephropathy. Background and Research Application PLA2R is the major auto-antigen in the autoimmune kidney disease, membranous nephropathy. Detection of PLA2R antigen by IHC in the immune complexes present in the glomerular basement membrane is used as a diagnostic marker for the disease. PLA2R is also involved in clearance followed by suppression of their potent enzymatic activities of secretory phospholipas… |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Fresquet et al. 2017. Sci Rep. 7(1):6876. PMID: 28761153. PLA2R binds to the annexin A2-S100A10 complex in human podocytes. Obrisca et al. 2015. Biomed Res Int. 2015:249740. PMID: 26576418. |
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