Anti-PDECGF [PGF 44C]

PD-ECGF expression is elevated in breast tumours and is a prognostic factor in colon tumours.

Contributors

Inventor Institute
Roy Bicknell University of Oxford
SKU: 151220
Product description: PD-ECGF expression is elevated in breast tumours and is a prognostic factor in colon tumours.
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 55 kDa (reduced)
Immunogen: Full length human protein in E. coli
Myeloma used: P3/NS1/1-Ag4.1
Cat. #: 151220
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Immunology;Tissue-specific biology
Application: IHC ; IF ; IP ; WB
Target: Platelet-derived endothelial cell growth factor (thymidine phosphorylase); PD-ECGF.
Reactivity: Human
Clone: PGF 44C
Host: Mouse
Class: Monoclonal
Target background: PD-ECGF expression is elevated in breast tumours and is a prognostic factor in colon tumours.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Weng et al. 2012. Basic Clin Pharmacol Toxicol. 110(3):298-306. PMID: 21973306.

Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression.

Ko et al. 2011. J Pharmacol Exp Ther. 338(1):184-94. PMID: 21444628.

Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells.

Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744.

DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer.

Fox et al. 1997. Ann Oncol. 8(3):271-5. PMID: 9137797.

Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF.

Fox et al. 1995. J Pathol. 176(2):183-90. PMID: 7636628.

Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: an immunohistochemical study.

Moghaddam et al. 1995. Proc Natl Acad Sci U S A. 92(4):998-1002. PMID: 7532308.

Thymidine phosphorylase is angiogenic and promotes tumor growth.

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