Antibody for PCNA (proliferating cell nuclear antigen), a key protein involved in cell cycle regulation, particularly during DNA replication and repair. Its dysregulation is linked to cancer development.
| Institute |
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| Helmholtz Munich Core Facility Monoclonal Antibodies |
| Cat. #: | 162378 |
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| Tool sub type: | Primary antibody |
| Cancer types: | Breast cancer |
| Research Fields: | Cancer;Cell biology |
| Application: | IP |
| Target: | Proliferating Cell Nuclear Antigen (PCNA) |
| Reactivity: | Human |
| Clone: | 16D10 |
| Host: | Rat |
| Class: | Monoclonal |
| Primary citation: | Spada et al. 2007. J Cell Biol. 176(5): 565-71. PMID: 17312023 |
| Alternate name: | Anti PCNA (clone 16D10) |
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| Product description: | Antibody for PCNA (proliferating cell nuclear antigen), a key protein involved in cell cycle regulation, particularly during DNA replication and repair. Its dysregulation is linked to cancer development. |
| Conjugation: | Unconjugated |
| Immunogen: | Recombinant 6xHis-tagged PCNA |
| Target background: | PCNA (Proliferating Cell Nuclear Antigen) is a sliding clamp for DNA polymerases during DNA replication that coordinates the orderly duplication of the genome by increasing the processivity of DNA polymerase delta. PCNA weighs approximately 29 kDa and forms a homotrimeric ring structure. It is expressed in the nucleus of cells found at high levels in proliferating cells. |
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| References: |
Spada et al. 2007. J Cell Biol. 176(5): 565-71. PMID: 17312023 |
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