Mucin 3 (MUC3) is a glycoprotein. Distributed in colon and rectum, and to a lesser extent in breast, lung and salivary gland tissues. Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling.
| Inventor | Institute |
|---|---|
| Mike Price | University of Nottingham |
| Cat. #: | 153400 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Colorectal cancer |
| Research Fields: | Cancer;Cell biology;Genetics |
| Application: | ELISA ; IHC |
| Target: | MUC3 |
| Reactivity: | Human |
| Clone: | 1143/B7 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | MUC3A; Mucin 3; Intestinal mucin-3A |
|---|---|
| Product description: | Mucin 3 (MUC3) is a glycoprotein. Distributed in colon and rectum, and to a lesser extent in breast, lung and salivary gland tissues. Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 22 kDa |
| Immunogen: | MUC3 tandem repeat peptide |
| Target background: | Mucin 3 (MUC3) is a glycoprotein. Distributed in colon and rectum, and to a lesser extent in breast, lung and salivary gland tissues. Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Rossi et al. 2012. Histopathology. 60(7):1133-43. PMID: 22348416. MUC5AC, cytokeratin 20 and HER2 expression and K-RAS mutations within mucinogenic growth in congenital pulmonary airway malformations. Teshima et al. 2011. J Anat. 219(3):410-7. PMID: 21679184. Development of human minor salivary glands: expression of mucins according to stage of morphogenesis. Louis et al. 2006. J Cell Biochem. 99(6):1616-27. PMID: 16823775. Selective induction of mucin-3 by hypoxia in intestinal epithelia. |
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