Anti-MR1 [8G3]

MR1 presents small metabolite antigens from diverse microbes to activate an abundant T cell population called mucosal associated invariant T cells (MAIT cells).

Contributors

Inventor Institute
Jose Villadangos ; Hamish McWilliam University of Melbourne
Cat. #: 160705
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cancer;Immunology
Application: IP ; WB
Target: MR1
Reactivity: Human ; Mouse
Host: Mouse
Class: Monoclonal
Alternate name: Major histocompatability complex class I-related gene protein
Product description: MR1 presents small metabolite antigens from diverse microbes to activate an abundant T cell population called mucosal associated invariant T cells (MAIT cells). In this way MR1 activates MAIT cells which results in anti-microbial immunity and tissue repair.
Conjugation: Unconjugated
Isotype: IgG2a kappa
Molecular weight: 42 kDa
Immunogen: Peptide sequence from MR1: pwmaenlapdhwer
Immunogen Uniprot ID: Q95460
Myeloma used: Sp2/0
Target background: MR1 presents small metabolite antigens from diverse microbes to activate an abundant T cell population called mucosal associated invariant T cells (MAIT cells). In this way MR1 activates MAIT cells which results in anti-microbial immunity and tissue repair.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

McWilliam et al. 2020. Proc Natl Acad Sci U S A. 117(40):24974-24985. PMID: 32958637.

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