Anti-MR1 [8G3]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-MR1 [8G3]
• Alternate name: Major histocompatability complex class I-related gene protein
• Research fields: Cancer;Immunology
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 42 kDa
• Strain: C57BL/6
• Reactivity: Human ; Mouse
• Host: Mouse
• Application: IP ; WB
• Description: MR1 presents small metabolite antigens from diverse microbes to activate an abundant T cell population called mucosal associated invariant T cells (MAIT cells). In this way MR1 activates MAIT cells which results in anti-microbial immunity and tissue repair.
• Immunogen: Peptide sequence from MR1: pwmaenlapdhwer
• Immunogen uniprot id: Q95460
• Isotype: IgG2a kappa
• Myeloma used: Sp2/0
• Recommended controls: The peptide or a lysate of cells expressing MR1

Target Details

• Target: MR1
• Molecular weight: 42 kDa
• Tissue cell line specificity: The peptide or a lysate of cells expressing MR1
• Target background: MR1 presents small metabolite antigens from diverse microbes to activate an abundant T cell population called mucosal associated invariant T cells (MAIT cells). In this way MR1 activates MAIT cells which results in anti-microbial immunity and tissue repair.

Applications

• Application: IP ; WB

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Dry ice

References

• McWilliam et al. 2020. Proc Natl Acad Sci U S A. 117(40):24974-24985. PMID: 32958637.