Cat. #153644
Anti-Myelin Basic Protein (region Thr98) [98/P12]
Cat. #: 153644
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Myelin Basic Protein (region Thr98)
Class: Monoclonal
Application: ELISA ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: BioServ UK Ltd
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Myelin Basic Protein (region Thr98) [98/P12]
- Alternate name: Myelin basic protein, MBP, 2 kDa microtubule-stabilizing protein, Myelin A1 protein
- Cancer: Neurological cancer
- Cancers detailed: Brain
- Research fields: Cell biology;Immunology;Neurobiology
- Clone: 98/P12
- Tool sub type: Primary antibody
- Class: Monoclonal
- Purpose: Marker
- Conjugation: Unconjugated
- Molecular weight: 13-21 kDa
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; WB
- Description: The phosphorylation of myelin basic protein (MBP) has been shown to decrease the ability of MBP to aggregate lipid vesicles and consequently destabilising the compact structure of myelin, a destruction that has been observed in demyelinating diseases such as Multiple Sclerosis. (Yon, M et al. 1995) Clone 98/P12 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.
- Immunogen: Synthetic peptide corresponding to human MBP when phosphorylated at threonine 98
- Isotype: IgG2a
- Myeloma used: Sp2/0-Ag14
- Recommended controls: Brain tissue
Target Details
- Target: Myelin Basic Protein (region Thr98)
- Molecular weight: 13-21 kDa
- Tissue cell line specificity: Mouse
- Target background: The phosphorylation of myelin basic protein (MBP) has been shown to decrease the ability of MBP to aggregate lipid vesicles and consequently destabilising the compact structure of myelin, a destruction that has been observed in demyelinating diseases such as Multiple Sclerosis. (Yon, M et al. 1995) Clone 98/P12 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.
Applications
- Application: ELISA ; WB
Handling
- Format: Liquid
- Unit size: 100 ug
- Shipping conditions: Dry ice
References
- DeBruin et al. 2006. Biochem Cell Biol. 84(6):993-1005. PMID: 17215885.
- Partitioning of myelin basic protein into membrane microdomains in a spontaneously demyelinating mouse model for multiple sclerosis.
- DeBruin et al. 2005. J Neurosci Res. 80(2):211-25. PMID: 15772981.
- Developmental partitioning of myelin basic protein into membrane microdomains.
- Atkins et al. 1999. J Neurochem. 73(3):1090-7. PMID: 10461899.
- Regulation of myelin basic protein phosphorylation by mitogen-activated p...
