Anti-Myelin Basic Protein (region Thr98) [98/P12]

Clone 98/P12 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.

Contributors

Institute
BioServ UK Ltd
Cat. #: 153644
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Brain cancer
Research Fields: Cell biology;Immunology;Neurobiology
Application: ELISA ; WB
Target: Myelin Basic Protein (region Thr98)
Reactivity: Human
Clone: 98/P12
Host: Mouse
Class: Monoclonal
Alternate name: Myelin basic protein, MBP, 2 kDa microtubule-stabilizing protein, Myelin A1 protein
Product description: The phosphorylation of myelin basic protein (MBP) has been shown to decrease the ability of MBP to aggregate lipid vesicles and consequently destabilising the compact structure of myelin, a destruction that has been observed in demyelinating diseases such as Multiple Sclerosis. (Yon, M et al. 1995) Clone 98/P12 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.
Conjugation: Unconjugated
Isotype: IgG2a
Molecular weight: 13-21 kDa
Immunogen: Synthetic peptide corresponding to human MBP when phosphorylated at threonine 98
Myeloma used: Sp2/0-Ag14
Target background: The phosphorylation of myelin basic protein (MBP) has been shown to decrease the ability of MBP to aggregate lipid vesicles and consequently destabilising the compact structure of myelin, a destruction that has been observed in demyelinating diseases such as Multiple Sclerosis. (Yon, M et al. 1995) Clone 98/P12 is a useful detector of phosphorylated MBP by binding to Thr98 of human MBP in the phosphorylated state.
Format: Liquid
Shipping conditions: Dry ice
References:

DeBruin et al. 2006. Biochem Cell Biol. 84(6):993-1005. PMID: 17215885.

Partitioning of myelin basic protein into membrane microdomains in a spontaneously demyelinating mouse model for multiple sclerosis.

DeBruin et al. 2005. J Neurosci Res. 80(2):211-25. PMID: 15772981.

Developmental partitioning of myelin basic protein into membrane microdomains.

Atkins et al. 1999. J Neurochem. 73(3):1090-7. PMID: 10461899.

Regulation of myelin basic protein phosphorylation by mitogen-activated p…

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ELISA using clone 98/P12 to test its immunoreactivity against synthetic peptides and proteins. Source

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