UCH-T2 is useful for detection of T cells in peripheral blood and lymph nodes and categorisation of T cell lymphomas and B cell chronic lymphocytic leukaemia.
| Inventor | Institute |
|---|---|
| Peter Beverley | University College London (UCL) |
| Cat. #: | 151176 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Cancer types: | Blood cancer |
| Research Fields: | Immunology;Stem cell biology |
| Application: | IHC ; IF ; WB |
| Target: | Leu1 (CD5) |
| Reactivity: | Human |
| Clone: | UCH-T2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Beverley & Callard. 1982. Protides Biol Fluids. 29:653-8. |
| Alternate name: | CD5 Molecule 2; Lymphocyte Antigen T1/Leu-1; LEU1; CD5 Antigen; T1 |
|---|---|
| Product description: | UCH-T2 is useful for detection of T cells in peripheral blood and lymph nodes and categorisation of T cell lymphomas and B cell chronic lymphocytic leukaemia. |
| Additional notes: | UCH-T1TM a registered trademark of Cancer Research Technology, Limited. All rights reserved. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Immunogen: | Thymocytes followed by Sezary T cells. |
| Immunogen Uniprot ID: | P04234 |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | Leu-1 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukaemia cells that binds CD72. Absence of the Leu-1 marker on childhood ALL cells is associated with a more favourable prognosis. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Beverley PE & Callard RE. 1982. Protides Biol. Fluids. Colloq. 29:653-8. Kap et al. 2009. J Histochem Cytochem. 57(12):1159-67. PMID: 19729671. A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. Gary-Gouy et al. 2007. J Immunol. 179(7):4335-44. PMID: 17878328. Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype. |
|---|
| Cat. # | Tool Name | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 151019 | Anti-Mos [S3.1] |
Key Info
Anti-Mos [S3.1]
|
View Tool | |||||||||||||||||||
| 151021 | Anti-CyclinB1 [V152] |
Key Info
Anti-CyclinB1 [V152]
|
View Tool | |||||||||||||||||||
| 151025 | Anti-Vascular endothelium [10] |
Key Info
Anti-Vascular endothelium [10]
|
View Tool | |||||||||||||||||||
| 151028 | Anti-Cytochrome P450 2C2, 2B1/2 [h7] |
Key Info
Anti-Cytochrome P450 2C2, 2B1/2 [h7]
|
View Tool | |||||||||||||||||||
| 151035 | Anti-CD8 [14] mAb |
Key Info
Anti-CD8 [14] mAb
|
View Tool | |||||||||||||||||||
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.