#151176

Anti-Leu1 [UCH-T2]

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Cat. #151176

Anti-Leu1 [UCH-T2]

Cat. #: 151176

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 1-2 weeks

Target: Leu1 (CD5)

Class: Monoclonal

Application: IHC ; IF ; WB

Reactivity: Human

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Peter Beverley

Institute: University College London (UCL)

Tool Details
Target Details
Applications
Handling
Related Tools
References
Documentation

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Leu1 [UCH-T2]
  • Alternate name: CD5 Molecule 2; Lymphocyte Antigen T1/Leu-1; LEU1; CD5 Antigen; T1
  • Cancer: Blood cancer
  • Cancers detailed: Leukemia;Lymphoma
  • Research fields: Immunology;Stem cell biology
  • Clone: UCH-T2
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Strain: Balb/c
  • Reactivity: Human
  • Host: Mouse
  • Application: IHC ; IF ; WB
  • Description: UCH-T2 is useful for detection of T cells in peripheral blood and lymph nodes and categorisation of T cell lymphomas and B cell chronic lymphocytic leukaemia.
  • Immunogen: Thymocytes followed by Sezary T cells.
  • Immunogen uniprot id: P04234
  • Isotype: IgG1 kappa
  • Myeloma used: P3/NS1/1-Ag4.1
  • Additional notes: UCH-T1Ě˝is a registered trademark of Cancer Research Technology, Limited. All rights reserved.

Target Details

  • Target: Leu1 (CD5)
  • Target background: Leu-1 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukaemia cells that binds CD72. Absence of the Leu-1 marker on childhood ALL cells is associated with a more favourable prognosis.

Applications

  • Application: IHC ; IF ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

Related Tools

  • Related tools: Anti-CD3, Recombinant [UCH-T1?‚™]

References

  • Beverley PE & Callard RE. 1982. Protides Biol. Fluids. Colloq. 29:653-8.
  • Kap et al. 2009. J Histochem Cytochem. 57(12):1159-67. PMID: 19729671.
  • A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates.
  • Gary-Gouy et al. 2007. J Immunol. 179(7):4335-44. PMID: 17878328.
  • Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype.

Documentation