Anti-Keratin19 [BA17]

Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 19 (a cytokeratin) is the smallest human keratin and is found in many […]

Contributors

Inventor Institute
Joyce Taylor-Papadimitriou Cancer Research UK, London Research Institute: Lincoln's Inn Fields
Cat. #: 151077
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction
Application: FACS ; IHC ; IP ; WB
Target: Keratin 19
Reactivity: Human
Clone: BA17
Host: Mouse
Class: Monoclonal
Product description: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 19 (a cytokeratin) is the smallest human keratin and is found in many simple and some non-keratinising stratified squamous epithelia. The degree of keratin 19 positivity in breast cancer distinguishes malignant from benign tumours. Keratin 19 is often co-expressed with keratin 7.
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: 40 kDa
Immunogen: Detergent-insoluble extract of human mammary epithelial organoids.
Myeloma used: P3X63Ag8.653
Target background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 19 (a cytokeratin) is the smallest human keratin and is found in many simple and some non-keratinising stratified squamous epithelia. The degree of keratin 19 positivity in breast cancer distinguishes malignant from benign tumours. Keratin 19 is often co-expressed with keratin 7.
Format: Liquid
Concentration: 0.9-1.1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Morton et al. 2008. Am J Pathol. 172(4):1081-7. PMID: 18310506.

Trp53 deletion stimulates the formation of metastatic pancreatic tumors.

Aleksic et al. 2007. Gut. 56(2):227-36. PMID: 16870717.

Cellular immune reaction in the pancreas is induced by constitutively active IkappaB kinase-2.

Nightingale et al. 2004. J Am Soc Nephrol. 15(1):21-32. PMID: 14694154.

Oncostatin M, a cytokine released by activated mononuclear cells, induces epithelial cell-myofibroblast transdifferentiation via Jak/Stat pathway activation.

Brtek et al. 1986. Eur J Cancer Clin Oncol. 22(12):1441-52. PMID: 2439341.

Expression of monoclonal antibody-defined epitopes of keratin 19 in human tumours and cultured cells.

Bartek et al. 1985. Int J Cancer. 36(3):299-306. PMID: 2411673.

Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours.

Bartek et al. 1985. J Cell Sci. 75:17-33. PMID: 2413060.

A subclass of luminal epithelial cells in the human mammary gland, defined by antibodies to cytokeratins.

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