Anti-Integrin Beta 3a (GPIIIa, CD61) [AP-3]

Monoclonal antibody specific for human glycoprotein IIIa.

Contributors

Inventor Institute
Richard Aster Versiti Blood Research Institute
Cat. #: 153746
Tool sub type: Primary antibody
Unit size: 100 ug
Research Fields: Immunology
Application: ELISA ; FACS
Target: Integrin Beta 3a (GPIIIa, CD61)
Host: Mouse
Class: Monoclonal
Alternate name: CD-61
Product description: Monoclonal antibody specific for human glycoprotein IIIa. Background and Research Application Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Glycoprotein IIb/IIIa, also known as integrin aIIbß3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrinogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder. This antibody is specific for amino acids 50-62 of GP11a.
Conjugation: Unconjugated
Isotype: IgG1
Molecular weight: ~ 86-87 kDa
Immunogen: Human platelet
Immunogen Uniprot ID: P05106
Target background: Monoclonal antibody specific for human glycoprotein IIIa. Background and Research Application Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Glycoprotein IIb/IIIa, also known as integrin aIIb?3 is an integrin complex found on platelets. The complex acts as a receptor for both fibrinogen and von Willebrand factor and helps in platelet activation. Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia, which is an abnormality in the platelets, or bleeding disorder. This antibody is specific for amino acids 50-62 of GP11a.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
Shipping conditions: Dry ice
References:

Faralli et al. 2019. Invest Ophthalmol Vis Sci. 60(5):1776-1788. PMID: 31022732.

Faralli et al. 2018. PLoS One. 13(3):e0192665. PMID: 29499052.

Peterson et al. 2008. Blood. 111(3):1234-9. PMID: 17959856.

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