| Inventor | Institute |
|---|---|
| Mike Horton | Queen Mary University of London |
| SKU: | 151133 |
|---|---|
| Product description: | The MHF4 epitope is different to the F11 epitope. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 118/100 |
| Immunogen: | A bone cell suspension containing osteoclasts, osteoblasts and bone marrow cells obtained from the long bones of newborn Sprague Dawley rats. |
| Myeloma used: | P3X63Ag8.653 |
| Cat. #: | 151133 |
|---|---|
| Provenance and Ownership: | The Anti-Integrin b3 [MHF4] is owned by Cancer Research UK. CancerTools supplies the Anti-Integrin b3 [MHF4] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-Integrin b3 [MHF4] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Tissue-specific biology;Cell signaling and signal transduction |
| Application: | FACS ; IHC ; FACS ; IHC ; IF ; IP |
| Target: | Integrin ?3 chain (CD61) |
| Reactivity: | Human ; Rat |
| Clone: | MHF4 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin b3 is expressed in osteoclasts, megacaryocytes and platelets. MHF4 may be used to identify osteoclasts in tissue sections and bone cell suspensions. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Human Adenovirus Type 37 Uses aV?1 and a3?1 Integrins for Infection of Human Corneal Cells. Storm et al. 2016. J Virol. :. PMID: 27974569. Ballana et al. 2011. J Immunol. 186(1):464-70. PMID: 21098231. ?5 integrin is the major contributor to the aVintegrin-mediated blockade of HIV-1 replication. Helfrich et al. 1992. J Bone Miner Res. 7(3):345-51. PMID: 1585837. Integrins on rat osteoclasts: characterization of two monoclonal antibodies (F4 and F11) to rat beta 3. |
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