Cat. #151543
Anti-Integrin aVb6 [AvB6 53a.2]
Cat. #: 151543
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: Integrin alpha v/beta 6
Class: Monoclonal
Application: FACS ; IF ; IP ; Fn
Reactivity: Human
Host: Rat
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: John Marshall
Institute: Queen Mary University of London
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Integrin aVb6 [AvB6 53a.2]
- Research fields: Cancer;Cell biology;Cell signaling and signal transduction;Stem cell biology;Tissue-specific biology
- Clone: AvB6 53a.2
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human
- Host: Rat
- Application: FACS ; IF ; IP ; Fn
- Description: Monoclonal antibody involved in carcinoma invasion, with high potential as a therapeutic target.
- Immunogen: Mouse fibroblasts retrovirally infected with cDNA to human beta6 (3T3b6.19). Cells expressed a mouse/human avb6 chimera.
- Immunogen uniprot id: P06756
- Isotype: IgG2a
- Recommended controls: BT20 breast carcinoma, original immunogen.
Target Details
- Target: Integrin alpha v/beta 6
- Tissue cell line specificity: BT20 breast carcinoma, original immunogen.
- Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells and aberrant integrin expression has been found in many epithelial tumours. The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes carcinoma invasion, fibrosis and correlates with poor survival and therefore makes a promising therapeutic target. This antibody does not recognize alpha V or other alpha V integrins.
Applications
- Application: FACS ; IF ; IP ; Fn
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
- Shipping conditions: Dry ice
References
- Liu et al. 2017. Exp Ther Med. 14(4):3880-3886. PMID: 29042996.
- Marsh et al. 2008. Cancer Res. 68(9):3295-303. PMID: 18451156.
- alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation.
