P256 induces aggregation of normal platelets in plasma.
| Inventor | Institute |
|---|---|
| Nancy Hogg | Imperial College |
| SKU: | 151138 |
|---|---|
| Product description: | P256 induces aggregation of normal platelets in plasma. |
| Alternate name: | alpha 2B/beta3, alphaIIbetabeta3, GPIIbetabeta3, CD41/CD61, platelet fibronectin receptor |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 135 kDa |
| Immunogen: | Peripheral blood mononuclear cells |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Cat. #: | 151138 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell signaling and signal transduction;Cell biology |
| Application: | IHC ; IF ; IP ; WB |
| Target: | Integrin a2b?3 (CD41 & CD61) |
| Reactivity: | Human |
| Clone: | P256 |
| Host: | Mouse |
| Class: | Monoclonal |
| Target background: | Integrins are heterodimeric cell surface receptors composed of a and ? subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin a2b (CD41) and integrin ?3 (CD61) associate to form the heterodimer integrin a2bb3 (CD41/CD61; GPIIb/IIIa), a fibronectin receptor expressed… |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Activation of platelets induced by mAb P256 specific for glycoprotein IIb-IIIa. Possible evidence for a role for IIb-IIIa in membrane signal transduction. 1989. Ann. Meeting Br. Nuclear Med. Soc. Abstracts. 243. In vivo studies with an anti-platelet monoclonal antibody P256. Monoclonal antibodies specific for platelet glycoproteins react with human monocytes. |
|---|
Please note we may take up to three days to respond to your enquiry.
CancerTools.org uses the contact information provided to respond to you about our research tools and service. For more information please review our privacy policy.