Anti-Integrin aEb7 [BP6]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-Integrin aEb7 [BP6]
• Research fields: Cell biology
• Clone: BP6
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Reactivity: Human
• Host: Mouse
• Application: IHC ; IP
• Description: BP6 may be used in the diagnosis of enteropathy-associated lymphoma and hairy cell leukaemia.
• Immunogen: Hairy cell spleen lysate
• Isotype: IgG1 kappa
• Myeloma used: P3/NS1/1-Ag4.1

Target Details

• Target: Integrin alpha E/?7 (CD103)
• Target background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha E/beta7 (aE/b7) is a heterodimer comprising a 150kDa alpha E chain and a 120kDa beta 7 chain. The expression of Integrin aE/b7 defines a developmentally important subset of T cells, namely mucosal T cells including all intraepithelial lymphocytes and ~20% of lamina propria T cells. Integrin aE/b7 is also a selective marker for intestinal intra-epithelial T-cells.

Applications

• Application: IHC ; IP

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Shipping at 4° C

References

• Micklem et al. 1991. Am J Pathol. 139(6):1297-301. PMID: 1750505.
• HML-1 antigen on mucosa-associated T cells, activated cells, and hairy leukemic cells is a new integrin containing the beta 7 subunit.