HIF1A has been observed in varying subsets of tumour cells from various solid tumours.
| Inventor | Institute |
|---|---|
| Helen Turley | University of Oxford |
| Cat. #: | 151260 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Genetics |
| Application: | ELISA ; IHC ; WB |
| Target: | Hypoxia-inducible factor 1, alpha subunit (HIF1A) |
| Reactivity: | Human |
| Clone: | ESEE122 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF1A has been observed in varying subsets of tumour cells from various solid tumours. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Immunogen: | GST-human HIF-1A amino acids 329-530 fusion protein |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | Induction of the Hif regulated genes, as a consequence of the microenvironment or genetic changes, is known to have an important role in the growth of experimental tumours. HIF1A has been observed in varying subsets of tumour cells from various solid tumours. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Giatromanolaki et al. 2003. J Pathol. 200(2):222-8. PMID: 12754744. DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. Hui et al. 2002. Clin Cancer Res. 8(8):2595-604. PMID: 12171890. Coexpression of hypoxia-inducible factors 1alpha and 2alpha, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival. Beasley et al. 2002. Cancer Res. 62(9):2493-7. PMID: 11980639. Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Talks et al. 2000. Am J Pathol. 157(2):411-21. PMID: 10934146. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Wiesener et al. 1998. Blood. 92(7):2260-8. PMID: 9746763. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. |
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