Anti-Gamma-ECS [11H7.C1.A2]

Contributors

Inventor Institute
Richard Meager University of Georgia
SKU: 153932
Product description: Together with glutathione synthetase and phytochelatin synthetase, gamma-glutamyl Cys sythetase (Î?-ECS) is an enzyme involved in, and required for, synthesizing phytochelatins (PC). Î?-ECS is involved in the biosynthesis of Glutathione. PC are multidentate ligands that are able to form chelates with thio-reactive, “soft” metal cations such as Cd2+, Hg2+, and at least one oxoanion (AsO33-). In certain plants, deficiency of such enzymes leads to low tolerance to metal contamination while mutants over-expressing them are highly tolerant to metal contamination and may be used in phyto-remediation of heavy metals.
Alternate name: ?-ECS
Conjugation: Unconjugated
Isotype: IgG2a
Immunogen: Synthetic peptide
Cat. #: 153932
Unit size: 100 ug
Research Fields: Cell signaling and signal transduction
Application: ELISA ; IF ; WB
Target: Gamma-Glutamylcysteine Synthetase
Reactivity: E.coli ; Plant ; Saccharomyces
Host: Mouse
Class: Monoclonal
Target background: Together with glutathione synthetase and phytochelatin synthetase, gamma-glutamyl Cys sythetase (Î?-ECS) is an enzyme involved in, and required for, synthesizing phytochelatins (PC). Î?-ECS is involved in the biosynthesis of Glutathione. PC are multidentate ligands that are able to form chelates with thio-reactive, “soft” metal cations such as Cd2+, Hg2+, and at least one oxoanion (AsO33-). In certain plants, deficiency of such enzymes leads to low tolerance to metal contamination while mutants over-expressing them are highly tolerant to metal contamination and may be used in phyto-remediation of heavy metals.
Format: Liquid
Shipping conditions: Dry ice
References:

LeBlanc et al. 2011. Int J Phytoremediation. 13(7):657-73. PMID: 21972493.

Enhanced arsenic tolerance of transgenic eastern cottonwood plants expressing gamma-glutamylcysteine synthetase.

Li et al. 2005. Environ Toxicol Chem. 24(6):1376-86. PMID: 16117113.

Arsenic and mercury tolerance and cadmium sensitivity in Arabidopsis plants expressing bacterial gamma-glutamylcysteine synthetase.

Dhankher et al. 2002. Nat Biotechnol. 20(11):1140-5. PMID: 12368812.

Engineering tolerance and hyperaccumulation of arsenic in plants by combining arsenate reductase and gamma-glutamylcysteine synthetase expression.

Li et al. 2001. Plant Physiol. 127(3):711-9. PMID: 11706154.

Rapid isolation of monoclonal antibodies. Monitoring enzymes in the phytochelatin synthesis pathway.

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