Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane.
| Inventor | Institute |
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| Chris Dean | The Institute of Cancer Research |
| SKU: | 153391 |
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| Product description: | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. |
| Alternate name: | ERBB2, Tyrosine kinase type cell surface receptor HER2, Human Epidermal Growth Factor Receptor 2, Proto-Oncogene C-ErbB-2, HER-2/Neu, HER2, Receptor Tyrosine-Protein Kinase ErbB-2 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Molecular weight: | 77 kDa |
| Immunogen: | Recombinant full length protein (Human) |
| Cat. #: | 153391 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Cell signaling and signal transduction |
| Application: | IHC ; IP ; WB |
| Target: | Erb-B2 |
| Reactivity: | Human |
| Clone: | ICR55 |
| Host: | Rat |
| Class: | Monoclonal |
| Target background: | Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Sain et al. 2006. Mol Cancer Ther. 5(5):1197-208. PMID: 16731752. Potentiation of paclitaxel activity by the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin in human ovarian carcinoma cell lines with high levels of activated AKT. Dean et al. 1993. Cell Biophys. 22(1-3):111-27. PMID: 7534210. Rat MAbs to the product of the c-erbB-2 proto-oncogene for diagnosis and therapy in breast cancer. |
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