Monoclonal antibody which binds ENTPD1, and reacts with Epstein Barr lymphoblastoid cell lines.
| Inventor | Institute |
|---|---|
| Martin Rowe | University of Birmingham |
| SKU: | 151580 |
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| Product description: | Monoclonal antibody which binds ENTPD1, and reacts with Epstein Barr lymphoblastoid cell lines. ACE2 reacted consistently with all Epstein Barr virus lymphoblastoid cell line (EB-LCL) tested, with a subpopulation of cells in some but not all EB virus genome-positive Burkitt lymphoma lines, but with none of a range of EB virus genome-negative cell lines of lymphoma or leukaemia origin. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 70-100 kDa |
| Immunogen: | EBV-transformed human B lymphoblastoid cell line |
| Immunogen Uniprot ID: | O75356 |
| Myeloma used: | P3X63Ag8.653 |
| Cat. #: | 151580 |
|---|---|
| Provenance and Ownership: | The Anti-ENTPD1 [AC2] is owned by Cancer Research UK. CancerTools supplies the Anti-ENTPD1 [AC2] under licence from Cancer Research UK and is the authorised source for its distribution. Sourcing Anti-ENTPD1 [AC2] directly from the IP owner ensures authenticity, provenance and compliance with all applicable licensing and research use requirements. |
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology; Immunology; Neurobiology; Tissue-specific biology |
| Application: | FACS ; IF ; IP ; WB |
| Target: | Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, CD39) |
| Reactivity: | Human |
| Clone: | AC2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Primary citation: | Rowe et al. 1982. Int J Cancer. 29(4):373-81. PMID: 6282762. |
| Target background: | ENTPD1 is a transmembrane glycoprotein of apparent molecular weight of 70-100 kD that has an Ectonucleoside triphosphate diphosphohydrolase-1 (NTPDase-1, ecto-apyrase) activity hydrolysing the alpha- and beta- phosphate residues of extracellular ATP or ADP. In haematopoietic tissues, it is primarily expressed on activated B, T and NK cells. It is also expressed on some endothelial cells and cardiac neurons, and helps regulate platelet activation, vascular inflammation, and cardiac norepinephrine release. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | Store at -20° C frozen. Avoid repeated freeze / thaw cycles |
| Shipping conditions: | Dry ice |
| References: |
Rowe et al. 1982. Int J Cancer. 29(4):373-81. PMID: 6282762. |
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