Regulatory B cells (Bregs) have been shown to play a role in inflammatory bowel disease (IBD) in humans, as B cell depletion in patients with IBD tends to aggravate the disease. Furthermore it has been demonstrated that co-transfer of eAg-exposed B cells improves symptoms of experimental colitis in the T cell transfer model of colitis. This eAg-specific B cell hybridoma offers a unique tool to investigate the immune response towards eAgÄËĂÂĂÂs in experimental colitis, and potentially, in human IBD.
| Inventor | Institute |
|---|---|
| Anders Elm Pedersen ; Mogens H Claesson | University of Copenhagen |
| SKU: | 153819 |
|---|---|
| Product description: | Regulatory B cells (Bregs) have been shown to play a role in inflammatory bowel disease (IBD) in humans, as B cell depletion in patients with IBD tends to aggravate the disease. Furthermore it has been demonstrated that co-transfer of eAg-exposed B cells improves symptoms of experimental colitis in the T cell transfer model of colitis. This eAg-specific B cell hybridoma offers a unique tool to investigate the immune response towards eAgÄËĂÂĂÂs in experimental colitis, and potentially,… |
| Conjugation: | Unconjugated |
| Cat. #: | 153819 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Other |
| Target: | Enteroantigen |
| Clone: | F8 |
| Class: | Monoclonal |
| Target background: | Regulatory B cells (Bregs) have been shown to play a role in inflammatory bowel disease (IBD) in humans, as B cell depletion in patients with IBD tends to aggravate the disease. Furthermore it has been demonstrated that co-transfer of eAg-exposed B cells improves symptoms of experimental colitis in the T cell transfer model of colitis. This eAg-specific B cell hybridoma offers a unique tool to investigate the immune response towards eAgÄËĂÂĂÂs in experimental colitis, and potentially,… |
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| Format: | Liquid |
|---|---|
| Concentration: | 0.9-1.1mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
In vitro cloning and regulatory potential of B cell hybridomas secreting entero-antigen specific antibody. |
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