Anti-DNA [m74-c1]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-DNA [m74-c1]
• Research fields: Immunology
• Class: Monoclonal
• Conjugation: Unconjugated
• Host: Mouse
• Application: ELISA
• Description: Monoclonal anti-DNA antibodies were generated from a spontaneous mouse model of Systemic Lupus Erythematosus (SLE) (NZB x NZW)F1 using standard methodologies for the generation of B-cell hybridomas. The mice spontaneously developed anti-DNA antibodies that contributed to SLE disease. The mice were neither immunized nor stimulated non-specifically. Hybridomas derived from these autoimmune mice provide the opportunity to analyse the structure, function, and biology of autoantibodies important to understanding their contribution to the pathogenesis of SLE. Table 1 provides a summary of the variable region structures and DNA specificity for the monoclonal anti-DNA autoantibodies generated.
• Immunogen uniprot id: N/A
• Isotype: IgG

Target Details

• Target: ssDNA and/or dsDNA
• Target background: Monoclonal anti-DNA antibodies were generated from a spontaneous mouse model of Systemic Lupus Erythematosus (SLE) (NZB x NZW)F1 using standard methodologies for the generation of B-cell hybridomas. The mice spontaneously developed anti-DNA antibodies that contributed to SLE disease. The mice were neither immunized nor stimulated non-specifically. Hybridomas derived from these autoimmune mice provide the opportunity to analyse the structure, function, and biology of autoantibodies important to understanding their contribution to the pathogenesis of SLE. Table 1 provides a summary of the variable region structures and DNA specificity for the monoclonal anti-DNA autoantibodies generated.

Applications

• Application: ELISA

Handling

• Format: Liquid
• Unit size: 100 ug
• Shipping conditions: Dry ice

References

• Marion et al. 1997. Methods. 11(1):3-11. PMID: 8990083.
• Tillman et al. 1992. J Exp Med. 176(3):761-79. PMID: 1512540.
• Marion et al. 1982. J Immunol. 128(2):668-74. PMID: 7198664.