Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles.
| Inventor | Institute |
|---|---|
| Karen Pulford | University of Oxford |
| Cat. #: | 151390 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Cell signaling and signal transduction |
| Application: | IHC ; IHC ; WB |
| Target: | Cytokeratins of 46, 48, 50, 55, 56, 56.5, 59, 61, 62, 64, 65, 66 and 67 kDa |
| Reactivity: | Human |
| Clone: | K20 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2a kappa |
| Molecular weight: | 46-67 kDa |
| Immunogen: | Hair keratin |
| Myeloma used: | P3/NS1/1-Ag4.1 |
| Target background: | Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | '-15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Pulford et al. 1985. Histopathology. 9(8):825-40. PMID: 2414204. Gatter et al. 1985. Histopathology. 9(8):805-23. PMID: 2414203. The characterization of two monoclonal anti-keratin antibodies and their use in the study of epithelial disorders. Human lung tumours: a correlation of antigenic profile with histological type. |
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