CYP39A1 (cytochrome P450, family 39, subfamily A, polypeptide 1), also known as 24- hydroxycholesterol 7-a-hydroxylase localises to both the microsome and the endoplasmic reticulum. Using heme groups as cofactors, CYP39A1 is involved in the bile acid metabolism and is specifically expressed in liver.
| Inventor | Institute |
|---|---|
| Ayham Alnabulsi | Vertebrate Antibodies Limited |
| Cat. #: | 152122 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction;Metabolism;Tissue-specific biology |
| Application: | ELISA ; IHC ; WB |
| Target: | CYP39A1-Cytochrome P450, family 39, subfamily A, polypeptide 1. |
| Reactivity: | Human |
| Clone: | M30P6D6 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | CYP39A1 (cytochrome P450, family 39, subfamily A, polypeptide 1), also known as 24- hydroxycholesterol 7-ÄÂ?-hydroxylase localises to both the microsome and the endoplasmic reticulum. Using heme groups as cofactors, CYP39A1 is involved in the bile acid metabolism and is specifically expressed in liver. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG3 kappa |
| Immunogen: | Ovalbumin-conjugated synthetic peptide CRIEYKQRI (C-terminal sequence). |
| Myeloma used: | P3X63Ag8.653 |
| Target background: | CYP39A1 (cytochrome P450, family 39, subfamily A, polypeptide 1), also known as 24- hydroxycholesterol 7-a-hydroxylase localises to both the microsome and the endoplasmic reticulum. Using heme groups as cofactors, CYP39A1 is involved in the bile acid metabolism and is specifically expressed in liver. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer. Swan et al. 2016. Oncotarget. :. PMID: 27341022. |
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