Cytochrome P450 2R1 (CYP2R1) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2R1 expressed in the liver is a microsomal vitamin D hydroxylase that converts vitamin D into 25-hydroxyvitamin […]
| Inventor | Institute |
|---|---|
| Ayham Alnabulsi | Vertebrate Antibodies Limited |
| Cat. #: | 152121 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction;Metabolism;Tissue-specific biology |
| Application: | ELISA ; IHC ; WB |
| Target: | CYP2R1, Cytochrome P450, family 2, subfamily R, polypeptide 1. |
| Reactivity: | Human ; Mouse |
| Clone: | M26-P6H1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Cytochrome P450 2R1 (CYP2R1) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2R1 expressed in the liver is a microsomal vitamin D hydroxylase that converts vitamin D into 25-hydroxyvitamin D (calcidiol), the major circulatory form of the vitamin. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 lambda |
| Immunogen: | Ovalbumin-conjugated synthetic peptide QPYLICAERR (C-terminal sequence). |
| Myeloma used: | P3X63Ag8.653 |
| Target background: | Cytochrome P450 2R1 (CYP2R1) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2R1 expressed in the liver is a microsomal vitamin D hydroxylase that converts vitamin D into 25-hydroxyvitamin D (calcidiol), the major circulatory form of the vitamin. |
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| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer. Swan et al. 2016. Oncotarget. :. PMID: 27341022. |
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