Cat. #152121
Anti-Cytochrome P450 2R1 [M26-P6H1]
Cat. #: 152121
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 3-4 weeks
Target: CYP2R1, Cytochrome P450, family 2, subfamily R, polypeptide 1.
Class: Monoclonal
Application: ELISA ; IHC ; WB
Reactivity: Human ; Mouse
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Ayham Alnabulsi
Institute: Vertebrate Antibodies Limited
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Cytochrome P450 2R1 [M26-P6H1]
- Research fields: Cancer;Cell signaling and signal transduction;Metabolism;Tissue-specific biology
- Clone: M26-P6H1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human ; Mouse
- Host: Mouse
- Application: ELISA ; IHC ; WB
- Description: Cytochrome P450 2R1 (CYP2R1) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2R1 expressed in the liver is a microsomal vitamin D hydroxylase that converts vitamin D into 25-hydroxyvitamin D (calcidiol), the major circulatory form of the vitamin.
- Immunogen: Ovalbumin-conjugated synthetic peptide QPYLICAERR (C-terminal sequence).
- Isotype: IgG1 lambda
- Myeloma used: P3X63Ag8.653
- Recommended controls: IHC: formalin-fixed, paraffin-embedded human kidney sections. WB: pooled liver microsomes.
Target Details
- Target: CYP2R1, Cytochrome P450, family 2, subfamily R, polypeptide 1.
- Tissue cell line specificity: IHC: formalin-fixed, paraffin-embedded human kidney sections. WB: pooled liver microsomes.
- Target background: Cytochrome P450 2R1 (CYP2R1) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2R1 expressed in the liver is a microsomal vitamin D hydroxylase that converts vitamin D into 25-hydroxyvitamin D (calcidiol), the major circulatory form of the vitamin.
Applications
- Application: ELISA ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Dry ice
References
- Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.
- Swan et al. 2016. Oncotarget. :. PMID: 27341022.
