Anti-Cytochrome P450 2A6 [RP1.2B4]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-Cytochrome P450 2A6 [RP1.2B4]
• Research fields: Cancer;Cell signaling and signal transduction;Metabolism;Tissue-specific biology
• Clone: RP1.2B4
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: WB
• Description: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Possesses low phenacetin O-deethylation activity.
• Immunogen: Human cytochrome P450 CYP2A6
• Isotype: IgG1 kappa
• Myeloma used: P3X63Ag8.653
• Recommended controls: western blot: Recombinant P450 - 0.49 pmol per lane.

Target Details

• Target: Cytochrome P450 2A6, CYP2A6
• Tissue cell line specificity: western blot: Recombinant P450 - 0.49 pmol per lane.
• Target background: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Possesses low phenacetin O-deethylation activity.

Applications

• Application: WB

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Dry ice

References

• Barnes, T. S. (1987). The generation and characterization of monoclonal antibodies to human cytochrome P450. Ph. D. Thesis. University of Aberdeen.