Cat. #152114
Anti-Cytochrome P450 26A1 [F27P6A1]
Cat. #: 152114
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: CYP26A1 Cytochrome P450 26A1 (Retinoic acid-metabolizing cytochrome) (P450 retinoicacid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase).
Class: Monoclonal
Application: ELISA ; IHC ; WB
Reactivity: Human
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Ayham Alnabulsi
Institute: Vertebrate Antibodies Limited
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Cytochrome P450 26A1 [F27P6A1]
- Research fields: Cancer;Cell signaling and signal transduction;Metabolism;Tissue-specific biology
- Clone: F27P6A1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 18.4 kDa
- Strain: Balb/c
- Reactivity: Human
- Host: Mouse
- Application: ELISA ; IHC ; WB
- Description: Mutations in CYP26A1 are associated with caudal agenesis and spina bifida. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryo.
- Immunogen: Ovalbumin-conjugated synthetic peptide PARFTHFHGE (C-terminal sequence)
- Isotype: IgG2b kappa
- Myeloma used: P3X63Ag8.653
- Recommended controls: IHC: formalin-fixed, paraffin-embedded liposarcoma sections. WB: over expression lysates
Target Details
- Target: CYP26A1 Cytochrome P450 26A1 (Retinoic acid-metabolizing cytochrome) (P450 retinoicacid-inactivating 1) (P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase).
- Molecular weight: 18.4 kDa
- Tissue cell line specificity: IHC: formalin-fixed, paraffin-embedded liposarcoma sections. WB: over expression lysates
- Target background: Mutations in CYP26A1 are associated with caudal agenesis and spina bifida. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryo.
Applications
- Application: ELISA ; IHC ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Stoney et al. 2015. Brain Struct Funct. :. PMID: 26374207.
- Expression of the retinoic acid catabolic enzyme CYP26B1 in the human brain to maintain signaling homeostasis.
- Brown et al. 2014. PLoS One. 9(3):e90776. PMID: 24608339.
- The expression and prognostic significance of retinoic acid metabolising enzymes in colorectal cancer.
- Downie et al. 2005. Clin Cancer Res. 11(20):7369-75. PMID: 16243809.
- Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers.
- Kumarakulasingham et al. 2005. Clin Cancer Res. 11(10):3758-65. PMID: 15897573.
- Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis.
