CYP1B1 is upregulated in tumour cells and is a therapeutic target
| Inventor | Institute |
|---|---|
| Ayham Alnabulsi | Vertebrate Antibodies Limited |
| Cat. #: | 152699 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell signaling and signal transduction;Metabolism;Tissue-specific biology |
| Application: | ELISA ; IHC ; WB |
| Target: | Cytochrome P450, Family 1, Subfamily B, Polypeptide 1, CYP1B1 |
| Reactivity: | Human ; Mouse ; Rat |
| Clone: | 500 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development. CYP1B1 is upregulated in tumour cells and is a therapeutic target |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 52 kDa |
| Immunogen: | Ovalbumin-conjugated synthetic peptide – PENFDPARFLDKDGL |
| Target background: | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.Participates in the metabolism of an as-yet-unknown biologically active molecule that is a participant in eye development. CYP1B1 is upregulated in tumour cells and is a therapeutic target |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
McFadyen et al. 1999. J Histochem Cytochem. 47(11):1457-64. PMID: 10544218. Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1. |
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