#151253

Anti-Cul1 [AS97.1]

Cat. #151253

Anti-Cul1 [AS97.1]

Cat. #: 151253

Sub-type: Primary antibody

Unit size: 100 ug

Availability: 1-2 weeks

Target: Cullin 1 (Cul1)

Class: Monoclonal

Application: IP ; WB ; IP ; WB

Reactivity: Human ; Mouse

Host: Mouse

£300.00

This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.

Contributor

Inventor: Julian Gannon

Institute: Cancer Research UK, London Research Institute: Clare Hall Laboratories

Tool Details
Target Details
Applications
Handling
References

Tool Details

*FOR RESEARCH USE ONLY

  • Name: Anti-Cul1 [AS97.1]
  • Clone: AS97.1
  • Tool sub type: Primary antibody
  • Class: Monoclonal
  • Conjugation: Unconjugated
  • Reactivity: Human ; Mouse
  • Host: Mouse
  • Application: IP ; WB ; IP ; WB
  • Description: Cul-1 is a subunit of the SCF (Skp1/Cul-1/F-box protein complex), an E3 ubiquitination ligase that is responsible for destruction of proteins during the S phase of the cell cycle.
  • Immunogen: Bacterially expressed full length recombinant human culllin 1. (Cul1)
  • Isotype: IgG2a
  • Myeloma used: Sp2/0-Ag14

Target Details

  • Target: Cullin 1 (Cul1)
  • Target background: Cul-1 is a subunit of the SCF (Skp1/Cul-1/F-box protein complex), an E3 ubiquitination ligase that is responsible for destruction of proteins during the S phase of the cell cycle.

Applications

  • Application: IP ; WB ; IP ; WB

Handling

  • Format: Liquid
  • Concentration: 1 mg/ml
  • Unit size: 100 ug
  • Storage buffer: PBS with 0.02% azide
  • Storage conditions: -15° C to -25° C
  • Shipping conditions: Shipping at 4° C

References

  • Ang et al. 2012. PLoS Biol. 10(3):e1001290. PMID: 22479149.
  • Mao et al. 2011. J Biol Chem. 286(37):32355-65. PMID: 21778237.
  • COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
  • Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines.