Cat. #151253
Anti-Cul1 [AS97.1]
Cat. #: 151253
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 1-2 weeks
Target: Cullin 1 (Cul1)
Class: Monoclonal
Application: IP ; WB ; IP ; WB
Reactivity: Human ; Mouse
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Inventor: Julian Gannon
Institute: Cancer Research UK, London Research Institute: Clare Hall Laboratories
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Cul1 [AS97.1]
- Research fields: Apoptosis and autophagy;Cancer;Cell biology
- Clone: AS97.1
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Reactivity: Human ; Mouse
- Host: Mouse
- Application: IP ; WB ; IP ; WB
- Description: Cul-1 is a subunit of the SCF (Skp1/Cul-1/F-box protein complex), an E3 ubiquitination ligase that is responsible for destruction of proteins during the S phase of the cell cycle.
- Immunogen: Bacterially expressed full length recombinant human culllin 1. (Cul1)
- Isotype: IgG2a
- Myeloma used: Sp2/0-Ag14
Target Details
- Target: Cullin 1 (Cul1)
- Target background: Cul-1 is a subunit of the SCF (Skp1/Cul-1/F-box protein complex), an E3 ubiquitination ligase that is responsible for destruction of proteins during the S phase of the cell cycle.
Applications
- Application: IP ; WB ; IP ; WB
Handling
- Format: Liquid
- Concentration: 1 mg/ml
- Unit size: 100 ug
- Storage buffer: PBS with 0.02% azide
- Storage conditions: -15° C to -25° C
- Shipping conditions: Shipping at 4° C
References
- Ang et al. 2012. PLoS Biol. 10(3):e1001290. PMID: 22479149.
- Mao et al. 2011. J Biol Chem. 286(37):32355-65. PMID: 21778237.
- COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
- Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines.
