Cul-1 is a subunit of the SCF (Skp1/Cul-1/F-box protein complex), an E3 ubiquitination ligase that is responsible for destruction of proteins during the S phase of the cell cycle.
| Inventor | Institute |
|---|---|
| Julian Gannon | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151253 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Apoptosis and autophagy;Cancer;Cell biology |
| Application: | IP ; WB ; IP ; WB |
| Target: | Cullin 1 (Cul1) |
| Reactivity: | Human ; Mouse |
| Clone: | AS97.1 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | Cul-1 is a subunit of the SCF (Skp1/Cul-1/F-box protein complex), an E3 ubiquitination ligase that is responsible for destruction of proteins during the S phase of the cell cycle. |
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| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Bacterially expressed full length recombinant human culllin 1. (Cul1) |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Cul-1 is a subunit of the SCF (Skp1/Cul-1/F-box protein complex), an E3 ubiquitination ligase that is responsible for destruction of proteins during the S phase of the cell cycle. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Ang et al. 2012. PLoS Biol. 10(3):e1001290. PMID: 22479149. Mao et al. 2011. J Biol Chem. 286(37):32355-65. PMID: 21778237. COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. Histone deacetylase inhibitor trichostatin A represses estrogen receptor alpha-dependent transcription and promotes proteasomal degradation of cyclin D1 in human breast carcinoma cell lines. |
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