Cat. #157947
Anti-Cereblon [3B12F7]
Cat. #: 157947
Sub-type: Primary antibody
Unit size: 100 ug
Availability: 10-12 weeks
Target: Cereblon
Class: Monoclonal
Application: WB ; IHC
Host: Mouse
£300.00
This fee is applicable only for non-profit organisations. If you are a for-profit organisation or a researcher working on commercially-sponsored academic research, you will need to contact our licensing team for a commercial use license.
Contributor
Institute: Ohio State University
Tool Details
*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)
- Name: Anti-Cereblon [3B12F7]
- Research fields: Cancer;Neurobiology
- Tool sub type: Primary antibody
- Class: Monoclonal
- Conjugation: Unconjugated
- Molecular weight: 51 kDa
- Host: Mouse
- Application: WB ; IHC
- Description: Cereblon (CRBN) is a 51 kDa protein encoded by the gene CRBN. This protein is a target of the immunomodulatory drugs thalidomide, lenalidomide, and pomalidomide that show substantial activity in several hematologic cancers, including multiple myeloma, acute myeloid leukemia, and chronic lymphocytic leukemia. Cereblon protein is known to bind calcium-activated potassium channels (KCNMA1 subtype) and mutations in the CRBN gene are linked to cognitive defects, including intellectual disability. Cereblon also interacts with E3 ubiquitin ligase and may play a key role in limb outgrowth in embryos.
- Immunogen: Peptide corresponding to sequence near the N-terminus of human cereblon
- Immunogen uniprot id: CRBN_HUMAN
Target Details
- Target: Cereblon
- Molecular weight: 51 kDa
- Target background: Cereblon (CRBN) is a 51 kDa protein encoded by the gene CRBN. This protein is a target of the immunomodulatory drugs thalidomide, lenalidomide, and pomalidomide that show substantial activity in several hematologic cancers, including multiple myeloma, acute myeloid leukemia, and chronic lymphocytic leukemia. Cereblon protein is known to bind calcium-activated potassium channels (KCNMA1 subtype) and mutations in the CRBN gene are linked to cognitive defects, including intellectual disability. Cereblon also interacts with E3 ubiquitin ligase and may play a key role in limb outgrowth in embryos.
Applications
- Application: WB ; IHC
Handling
- Format: Liquid
- Unit size: 100 ug
- Shipping conditions: Shipping at 4° C
