Anti-CEACAM8 (CD66b) [6/40c]

Monoclonal antibody directed against CEACAM8, used to investigate cell signalling-mediated effects on immune responses, including in cancer cells.

Contributors

Inventor Institute
Bernhard B. Singer LeukoCom
Cat. #: 153323
Tool sub type: Primary antibody
Unit size: 100 ug
Cancer types: Digestive / Gastrointestinal cancer
Research Fields: Immunology
Application: ELISA ; FACS ; IHC ; IP ; WB
Target: CEACAM8, CD66b; CD67
Reactivity: Human
Clone: 6/40c
Host: Mouse
Class: Monoclonal
Alternate name: CD66b; CD67
Product description: Monoclonal antibody directed against CEACAM8, used to investigate cell signalling-mediated effects on immune responses, including in cancer cells. Background and Research Application The carcino-embryonic antigen-related cell adhesion molecule 8 (CEACAM8) is a glycosylphosphatidylinositol (GPI)-linked protein also known as CD67, CGM6, and NCA-95. CEACAM8 is a member of the immunoglobulin superfamily, carcinoembryonic antigen (CEA)-like subfamily. CEACAM8, expressed on granulocytes, has been reported to induce activation in neutrophils and to be involved in heterophilic adhesion with CEACAM6. It is not expressed by peripheral blood monocytes or lymphocytes. CEACAM8 is stored in specific vesicles of granulocytes and acts as a marker for specific vesicles for exocytosis. The soluble form of CEACAM8 binds to CEACAM1, a trans-membrane-bound molecule expressed by certain normal epithelial, endothelial, different leukocyte subpopulations and some cancer cells.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Molecular weight: 100 kDa
Immunogen: Recombinant soluble human CEACAM8-Fc produced in HEK293 cells
Immunogen Uniprot ID: P31997
Myeloma used: P3/NS1/1-Ag4.1
Target background: Monoclonal antibody directed against CEACAM8, used to investigate cell signalling-mediated effects on immune responses, including in cancer cells. Background and Research Application The carcino-embryonic antigen-related cell adhesion molecule 8 (CEACAM8) is a glycosylphosphatidylinositol (GPI)-linked protein also known as CD67, CGM6, and NCA-95. CEACAM8 is a member of the immunoglobulin superfamily, carcinoembryonic antigen (CEA)-like subfamily. CEACAM8, expressed on granulocytes, has been reported to induce activation in neutrophils and to be involved in heterophilic adhesion with CEACAM6. It is not expressed by peripheral blood monocytes or lymphocytes. CEACAM8 is stored in specific vesicles of granulocytes and acts as a marker for specific vesicles for exocytosis. The soluble form of CEACAM8 binds to CEACAM1, a trans-membrane-bound molecule expressed by certain normal epithelial, endothelial, different leukocyte subpopulations and some cancer cells.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
Shipping conditions: Dry ice
References:

Singer et al. 2014. PLoS One. 9(4):e94106. PMID: 24743304.

Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses.

Klaile et al. 2013. Respir Res. 14:85. PMID: 23941132.

Carcinoembryonic antigen (CEA)-related cell adhesion molecules are co-expressed in the human lung and their expression can be modulated in bronchial epithelial cells by non-typable Haemophilus influenzae, Moraxella catarrhalis, TLR3, and type I and II int

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