AN21.2 is useful as a general CDK antibody since it reacts with both Cdk1 and Cdk2.
| Inventor | Institute |
|---|---|
| Julian Gannon | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151245 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cancer;Cell biology;Genetics |
| Application: | ELISA ; WB |
| Target: | Cyclin-dependent kinase 2 (cdk2) |
| Reactivity: | Human ; Mouse ; Xenopus laevis |
| Clone: | AN21.2 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Cyclin-Dependent Kinase 2; Cell Division Protein Kinase 2; P33 Protein Kinase; CDKN2; CDC2-Related Protein Kinase; P33(CDK2) |
|---|---|
| Product description: | AN21.2 is useful as a general CDK antibody since it reacts with both Cdk1 and Cdk2. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Human recombinant Cdk2 |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Cdk2 is a cell cycle protein closely related to Cdk1 (Cdc2) and a useful marker of proliferation. Cdk2 binds cyclins A and E and controls progression into S-phase. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | '-15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Lee et al. 2012. Evid Based Complement Alternat Med. 2012:702857. PMID: 22701509. Inhibition of Cell Growth and Induction of Apoptosis by Antrodia camphorata in HER-2/neu-Overexpressing Breast Cancer Cells through the Induction of ROS, Depletion of HER-2/neu, and Disruption of the PI3K/Akt Signaling Pathway. Huang et al. 2008. Cell Cycle. 7(18):2846-55. PMID: 18769144. ATM kinase is a master switch for the Delta Np63 alpha phosphorylation/degradation in human head and neck squamous cell carcinoma cells upon DNA damage. |
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