Fizzy protein (cdc20) is associated with the activation of the anaphase-promoting complex (APC) at the onset of anaphase.
| Inventor | Institute |
|---|---|
| Julian Gannon | Cancer Research UK, London Research Institute: Clare Hall Laboratories |
| Cat. #: | 151302 |
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| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Biochemistry;Cell biology |
| Application: | ELISA ; FACS ; WB |
| Target: | Cell division cycle protein 20 (cdc20) |
| Reactivity: | Xenopus laevis |
| Clone: | BA8 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | APC/C activator protein CDC2; Cell division control protein 2; YGL116W; Cell Division Cycle 2; P55CDC; CDC2 Cell Division Cycle 2; BA276H19.3; CDC2A |
|---|---|
| Product description: | Fizzy protein (cdc20) is associated with the activation of the anaphase-promoting complex (APC) at the onset of anaphase. |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Immunogen: | Peptide from the carboxy terminus of the protein. |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Fizzy protein (cdc20) is associated with the activation of the anaphase-promoting complex (APC) at the onset of anaphase. |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Ohe et al. 2010. Mol Biol Cell. 21(6):905-13. PMID: 20089832. Emi2 inhibition of the anaphase-promoting complex/cyclosome absolutely requires Emi2 binding via the C-terminal RL tail. Sironi et al. 2001. EMBO J. 20(22):6371-82. PMID: 11707408. Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint. Lorca et al. 1998. EMBO J. 17(13):3565-75. PMID: 9649427. Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts. |
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