Anti-CD74 [BU45]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-CD74 [BU45]
• Alternate name: HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain; Cluster of Differentiation 74
• Cancer type: Bladder cancer
• Cancers detailed: Bladder
• Research fields: Immunology
• Clone: BU45
• Tool sub type: Primary antibody
• Class: Monoclonal
• Purpose: Marker
• Conjugation: Unconjugated
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: IHC
• Description: CD74 is expressed primarily by antigen presenting cells such as B lymphocytes , macrophages and monocytes together, with many epithelialcells. CD74 may exist in different isoforms ranging in size from 33 to 41kDa, depending on genetic splicing. CD74 is a type II transmembrane protein which binds to the binding groove of nacent MHC class II alpha/beta heterodimers preventing their premature association with endogenous polypeptides. The half life of CD74 on the cell surface is relatively short ...
• Immunogen: B lymphoblastoid cell line: HFB1
• Isotype: IgG1

Target Details

• Target: CD74
• Tissue cell line specificity: Mouse
• Target background: CD74 is expressed primarily by antigen presenting cells such as B lymphocytes , macrophages and monocytes together, with many epithelialcells. CD74 may exist in different isoforms ranging in size from 33 to 41kDa, depending on genetic splicing. CD74 is a type II transmembrane protein which binds to the binding groove of nacent MHC class II alpha/beta heterodimers preventing their premature association with endogenous polypeptides. The half life of CD74 on the cell surface is relatively short ...

Applications

• Application: IHC

Handling

• Format: Liquid
• Concentration: 0.9-1.1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: -15° C to -25° C
• Shipping conditions: Dry ice

References

• Leucocyte Typing IV, (1989): edited by W. Knapp, OUP, Oxford.
• Leucocyte Typing V, (1995): edited by S.F. Schlossman, OUP, Oxford.
• Wraight et al. 1990. J Biol Chem. 265(10):5787-92. PMID: 1690714.
• Human major histocompatibility complex class II invariant chain is expressed on the cell surface.