CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: […]
| Inventor | Institute |
|---|---|
| Martin Humphries | University of Manchester |
| Cat. #: | 152486 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Apoptosis and autophagy;Cell biology;Cell signaling and signal transduction;Immunology |
| Application: | ELISA ; Fn |
| Target: | Integrin alpha5 (CD49e) |
| Reactivity: | Human |
| Clone: | SNAKA52 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Integrin Subunit Alpha 5; Fibronectin Receptor Subunit Alpha; CD49 Antigen-Like Family Member E; Integrin Alpha-F; VLA-5; FNRA; Very Late Activation Protein 5; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Fibronectin Receptor; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Integrin Alpha; CD49e Antigen; CD49e; VLA5A |
|---|---|
| Product description: | CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECM… |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Immunogen: | a5?1 purified from human placenta. |
| Myeloma used: | P3X63Ag8.653 |
| Target background: | CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECM… |
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| Format: | Liquid |
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| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773. A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation. Mould et al. 2003. J Biol Chem. 278(19):17028-35. PMID: 12615914. Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement. Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligan… |
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