Anti-CD11c (Integrin aX) [3.9]

Tool Details

*FOR RESEARCH USE ONLY (for other uses, please contact the licensing team)

• Name: Anti-CD11c (Integrin aX) [3.9]
• Alternate name: CD11 antigen-like family member C, Leu M5, Leukocyte adhesion glycoprotein p15,95 alpha chain, Leukocyte adhesion receptor p15,95, CD antigen: CD11c
• Research fields: Cell biology;Cell signaling and signal transduction;Immunology;Stem cell biology
• Clone: 3.9
• Tool sub type: Primary antibody
• Class: Monoclonal
• Conjugation: Unconjugated
• Molecular weight: 150 kDa
• Strain: Balb/c
• Reactivity: Human
• Host: Mouse
• Application: FACS ; IHC ; IF ; IP ; Fn
• Description: Monoclonal antibody directed against CD11c antigen detects presence of macrophages, mononuclear phagocytes, hairy cell leukaemia cells and various activated T cells and neutrophils.
• Immunogen: Rheumatoid synovial fluid cells and fibronectin purified human monocytes
• Immunogen uniprot id: P20702
• Isotype: IgG1
• Myeloma used: Sp2/0-Ag14
• Recommended controls: Peripheral blood monocytes (PBMCs) (FACS), Uterine tissue sections (IHC)

Target Details

• Target: Integrin alpha X (CD11c; gp150/95 a subunit)
• Molecular weight: 150 kDa
• Tissue cell line specificity: Peripheral blood monocytes (PBMCs) (FACS), Uterine tissue sections (IHC)
• Target background: Anti-CD11c (integrin aX) was created to understand the expression of the integrin aX molecule and to look at the heterogeneity of tissue macrophages. Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells and aberrant integrin expression has been found in many epithelial tumours. Integrin alpha X is found on hairy cell leukaemia's, malignant histiocytes, on tissue macrophages, monocytes, activated neutrophils and some T-cell clones. It is a member of the LFA-1 CR3 family of human leukocyte differentiation antigens. This antibody binds to CD11c glycoprotein which helps mediate cellular adhesion and cell-matrix adhesion such as fibronectin.

Applications

• Application: FACS ; IHC ; IF ; IP ; Fn

Handling

• Format: Liquid
• Concentration: 1 mg/ml
• Unit size: 100 ug
• Storage buffer: PBS with 0.02% azide
• Storage conditions: Store at -20° C frozen. Avoid repeated freeze / thaw cycles
• Shipping conditions: Shipping at 4° C

References

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