The integrin alpha X chain protein (CD11c) belongs to the ?Ÿ2 integrin subfamily. Integrins are cell surface receptors composed of a heterodimer containing an a and ?Ÿ subunit. CD11c (the a subunit) combines with CD18 (the ?Ÿ subunit) to form the leukocyte specific integrin inactivated-C3b receptor 41,2. CD11c is known to be expressed on monocytes/macrophages, […]
| Inventor | Institute |
|---|---|
| Jacqueline Cordell | University of Oxford |
| Cat. #: | 151790 |
|---|---|
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Cell signaling and signal transduction;Immunology;Stem cell biology |
| Application: | IHC |
| Target: | CD11C, Integrin, alpha X (complement component 3 receptor 4 subunit). ITGAX |
| Reactivity: | Human |
| Clone: | 118/A5 |
| Host: | Mouse |
| Class: | Monoclonal |
| Product description: | The integrin alpha X chain protein (CD11c) belongs to the ?ĂÂ2 integrin subfamily. Integrins are cell surface receptors composed of a heterodimer containing an a and ?ĂÂ subunit. CD11c (the a subunit) combines with CD18 (the ?ĂÂ subunit) to form the leukocyte specific integrin inactivated-C3b receptor 41,2. CD11c is known to be expressed on monocytes/macrophages, granulocytes, activated B cells, in spleen and in bone marrow. |
|---|---|
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Immunogen: | Synthetic peptide conjugated to KLH corresponding to the C terminus of human CD11C: ANGQIAPENGTQTPSPPSEK |
| Myeloma used: | NS0 |
| Target background: | The integrin alpha X chain protein (CD11c) belongs to the ?ĂÂ2 integrin subfamily. Integrins are cell surface receptors composed of a heterodimer containing an a and ?ĂÂ subunit. CD11c (the a subunit) combines with CD18 (the ?ĂÂ subunit) to form the leukocyte specific integrin inactivated-C3b receptor 41,2. CD11c is known to be expressed on monocytes/macrophages, granulocytes, activated B cells, in spleen and in bone marrow. |
|---|
| Format: | Liquid |
|---|---|
| Concentration: | 1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Ihanus et al. 2007. Blood. 109(2):802-10. PMID: 16985175. Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4. Ammon et al. 2000. Immunology. 100(3):364-9. PMID: 10929059. Comparative analysis of integrin expression on monocyte-derived macrophages and monocyte-derived dendritic cells. Bilsland et al. 1994. J Immunol. 152(9):4582-9. PMID: 7512600. The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain. Myones et al. 1988. J Clin Invest. 82(2):640-51. PMID: 2969921. Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3. |
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