aM?2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation
| Institute |
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| Netherlands Cancer Institute |
| Cat. #: | 154771 |
|---|---|
| Tool sub type: | Primary antibody |
| Unit size: | 100 ug |
| Research Fields: | Cell biology;Cell signaling and signal transduction;Immunology |
| Application: | FACS ; IP |
| Target: | CD11b/CR3 |
| Reactivity: | Human |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | ITGAM; Leukocyte Adhesion Receptor MO1 |
|---|---|
| Product description: | ITGAM is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (ÄÂ?MÄÂ?2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). The second chain of ÄÂ?MÄÂ?2 is the common integrin ÄÂ?2 subunit known as CD18, and integrin ÄÂ?MÄÂ?2 thus belongs to the ÄÂ?2 subfamily (or leukocyte) integrins. ÄÂ?MÄÂ?2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Molecular weight: | 160 kDa |
| Immunogen: | The mouse was immunized with purified human monocytes |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | ITGAM is one protein subunit that forms heterodimeric integrin alpha-M beta-2 (aM?2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). The second chain of aM?2 is the common integrin ?2 subunit known as CD18, and integrin aM?2 thus belongs to the ?2 subfamily (or leukocyte) integrins. aM?2 is expressed on the surface of many leukocytes involved in the innate immune system, including monocytes, granulocytes, macrophages, and natural killer cells. It mediates inflammation by regulating leukocyte adhesion and migration and has been implicated in several immune processes such as phagocytosis, cell-mediated cytotoxicity, chemotaxis and cellular activation |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1 mg/ml |
| Storage buffer: | PBS with 0.02% azide |
| Storage conditions: | -15° C to -25° C |
| Shipping conditions: | Dry ice |
| References: |
Keizer et al. 1985. Eur J Immunol. 15(11):1142-8. PMID: 2933266. |
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