Centrosomal Protein 250 (CEP250), also known as Centrosomal Nek2-Associated Protein 1 (C-NAP1), is a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. CEP250 dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also […]
| Inventor | Institute |
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| Ciaran Morrison | National University of Ireland, Galway ; Centre For Chromosome Biology |
| Cat. #: | 153171 |
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| Unit size: | 100 ug |
| Research Fields: | Cell biology;Immunology |
| Application: | IHC ; WB ; IHC ; IP ; WB |
| Target: | Centrosomal Nek2-Associated Protein 1 |
| Reactivity: | Human |
| Clone: | 6F2C8 |
| Host: | Mouse |
| Class: | Monoclonal |
| Alternate name: | Centrosome-associated protein CEP25; Centrosomal Protein 25; Centrosomal Protein 25kDa; Centrosomal Nek2-Associated Protein 1; 25 KDa Centrosomal Protein; Centrosomal Protein 2; C-NAP1; CNAP1 |
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| Product description: | Centrosomal Protein 250 (CEP250), also known as Centrosomal Nek2-Associated Protein 1 (C-NAP1), is a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. CEP250 dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 kappa |
| Molecular weight: | 250 |
| Immunogen: | Recombinant human C-NAP1 amino acids 1513-1750 (bacterially expressed from pGEX4T as a GST fusion, then thrombin-cleaved and purified). |
| Myeloma used: | Sp2/0-Ag14 |
| Target background: | Centrosomal Protein 250 (CEP250), also known as Centrosomal Nek2-Associated Protein 1 (C-NAP1), is a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. CEP250 dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome. |
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| Format: | Liquid |
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| Concentration: | 0.9-1.1mg/ml |
| Storage buffer: | DMEM + 10% FBS + hypoxanthine supplement + non-essential amino acids |
| Storage conditions: | -20° C |
| Shipping conditions: | Dry ice |
| References: |
Flanagan et al. 2017. Mol Biol Cell. :. PMID: 28100636 |
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