Anti-c-Met [12.1]

c-Met is a tyrosine receptor kinase which is activated by its ligand, the hepatocyte growth factor. Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met is abnormally activated in many tumour types. Aberrant c-Met activation was found to induce tumour development, tumour cell migration and invasion, and the worst and final step in cancer progression, metastasis.

Contributors

Inventor Institute
Julin Wong ; David Lane University of Dundee
SKU: 152153
Product description: c-Met is a tyrosine receptor kinase which is activated by its ligand, the hepatocyte growth factor. Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met is abnormally activated in many tumour types. Aberrant c-Met activation was found to induce tumour development, tumour cell migration and invasion, and the worst and final step in cancer progression, metastasis.
Conjugation: Unconjugated
Isotype: IgG1 kappa
Immunogen: Bacterially expressed human c-Met alpha chain
Myeloma used: Sp2/0-Ag14
Cat. #: 152153
Tool sub type: Primary antibody
Unit size: 100 ug
Application: IF ; IP ; WB
Target: c-Met, cMet
Reactivity: Human
Clone: 12.1
Host: Mouse
Class: Monoclonal
Target background: c-Met is a tyrosine receptor kinase which is activated by its ligand, the hepatocyte growth factor. Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met is abnormally activated in many tumour types. Aberrant c-Met activation was found to induce tumour development, tumour cell migration and invasion, and the worst and final step in cancer progression, metastasis.
Format: Liquid
Concentration: 1 mg/ml
Storage buffer: PBS with 0.02% azide
Storage conditions: -15° C to -25° C
Shipping conditions: Dry ice
References:

Wong et al. 2013. Oncotarget. 4(7):1019-36. PMID: 23859937.

Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth.

Images

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Detection of endogenous c-Met in SNU-5 (c-Met positive) and T47D (c-Met negative) cells by immunofluorescence using purified anti-alpha-chain monoclonal antibodies.

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